Ontology highlight
ABSTRACT:
SUBMITTER: Minkah N
PROVIDER: S-EPMC4036618 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Minkah Nana N Chavez Kevin K Shah Parth P Maccarthy Thomas T Chen Hui H Landau Nathaniel N Krug Laurie T LT
Virology 20140313
Humans encode seven APOBEC3 (A3A-A3H) cytidine deaminase proteins that differ in their expression profiles, preferred nucleotide recognition sequence and capacity for restriction of RNA and DNA viruses. We identified APOBEC3 hotspots in numerous herpesvirus genomes. To determine the impact of host APOBEC3 on herpesvirus biology in vivo, we examined whether murine APOBEC3 (mA3) restricts murine gammaherpesvirus 68 (MHV68). Viral replication was impaired by several human APOBEC3 proteins, but not ...[more]