Ontology highlight
ABSTRACT:
SUBMITTER: Delebecque F
PROVIDER: S-EPMC1346872 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Delebecque Frédéric F Suspène Rodolphe R Calattini Sara S Casartelli Nicoletta N Saïb Ali A Froment Alain A Wain-Hobson Simon S Gessain Antoine A Vartanian Jean-Pierre JP Schwartz Olivier O
Journal of virology 20060101 2
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV. We show that human APOBEC3G is a potent inhibitor of FV infectivity in cell culture experiments. This antiviral activity is associated with cytidine editing of the viral genome. Both molecular F ...[more]