Ontology highlight
ABSTRACT:
SUBMITTER: Berndt N
PROVIDER: S-EPMC4037130 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Berndt Norbert N Hamilton Andrew D AD Sebti Saïd M SM
Nature reviews. Cancer 20111024 11
Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid post-translational modifications that are required for the transforming activity of many oncogenic proteins, including some RAS family members. This observation prompted the development of inhibitors of farnesyltransferase (FT) and geranylgeranyl-transferase 1 (GGT1) as potential anticancer drugs. In this Review, we discuss the mechanisms by which FT and GGT1 inhibitors (FTIs and GGTIs, respectively) af ...[more]