Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.
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ABSTRACT:
SUBMITTER: Zhao R
PROVIDER: S-EPMC4037409 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers.
Zhao Ruogang R Boudou Thomas T Wang Wei-Gang WG Chen Christopher S CS Reich Daniel H DH
Advanced materials (Deerfield Beach, Fla.) 20130128 12
A novel bio-magnetomechanical microtissue system is described for magnetic actuation of arrays of 3D microtissues using microcantilevers. This system enables both in situ measurements of fundamental mechanical properties of engineered tissue, such as contractility and stiffness, as well as dynamic stimulation of the microtissues. Using this system, cell and extracellular matrix contributions to the tissue mechanical properties are decoupled for the first time under both static and dynamic loadin ...[more]
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