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Genetics and genomics of alcohol sensitivity.


ABSTRACT: Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well as human populations that represent our current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system.

SUBMITTER: Morozova TV 

PROVIDER: S-EPMC4037586 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Genetics and genomics of alcohol sensitivity.

Morozova Tatiana V TV   Mackay Trudy F C TF   Anholt Robert R H RR  

Molecular genetics and genomics : MGG 20140107 3


Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well a  ...[more]

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