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Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates.

ABSTRACT: Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.

SUBMITTER: Soloff AC

PROVIDER: S-EPMC4038140 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates.

Soloff Adam C AC Bissel Stephanie J SJ Junecko Beth Fallert BF Giles Brendan M BM Reinhart Todd A TA Ross Ted M TM Barratt-Boyes Simon M SM

The Journal of infectious diseases 20140107 12

Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macr ...[more]

PMID: 24403559

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