Cellular origins of auditory event-related potential deficits in Rett syndrome.
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ABSTRACT:
SUBMITTER: Goffin D
PROVIDER: S-EPMC4038660 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Cellular origins of auditory event-related potential deficits in Rett syndrome.
Goffin Darren D Brodkin Edward S ES Blendy Julie A JA Siegel Steve J SJ Zhou Zhaolan Z
Nature neuroscience 20140428 6
Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic interneurons led to deficits in auditory event-related potentials and seizure manifestation, whereas the restoration of MeCP2 in specific classes of interneurons ameliorated these defic ...[more]
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