Protein phosphatases in pancreatic islets.
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ABSTRACT:
SUBMITTER: Ortsater H
PROVIDER: S-EPMC4038671 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Protein phosphatases in pancreatic islets.
Ortsäter Henrik H Grankvist Nina N Honkanen Richard E RE Sjöholm Åke Å
The Journal of endocrinology 20140328 3
The prevalence of diabetes is increasing rapidly worldwide. A cardinal feature of most forms of diabetes is the lack of insulin-producing capability, due to the loss of insulin-producing β-cells, impaired glucose-sensitive insulin secretion from the β-cell, or a combination thereof, the reasons for which largely remain elusive. Reversible phosphorylation is an important and versatile mechanism for regulating the biological activity of many intracellular proteins, which, in turn, controls a varie ...[more]
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