Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
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SUBMITTER: Moayyeri A
PROVIDER: S-EPMC4038791 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
Moayyeri Alireza A Hsu Yi-Hsiang YH Karasik David D Estrada Karol K Xiao Su-Mei SM Nielson Carrie C Srikanth Priya P Giroux Sylvie S Wilson Scott G SG Zheng Hou-Feng HF Smith Albert V AV Pye Stephen R SR Leo Paul J PJ Teumer Alexander A Hwang Joo-Yeon JY Ohlsson Claes C McGuigan Fiona F Minster Ryan L RL Hayward Caroline C Olmos José M JM Lyytikäinen Leo-Pekka LP Lewis Joshua R JR Swart Karin M A KM Masi Laura L Oldmeadow Chris C Holliday Elizabeth G EG Cheng Sulin S van Schoor Natasja M NM Harvey Nicholas C NC Kruk Marcin M del Greco M Fabiola F Igl Wilmar W Trummer Olivia O Grigoriou Efi E Luben Robert R Liu Ching-Ti CT Zhou Yanhua Y Oei Ling L Medina-Gomez Carolina C Zmuda Joseph J Tranah Greg G Brown Suzanne J SJ Williams Frances M FM Soranzo Nicole N Jakobsdottir Johanna J Siggeirsdottir Kristin K Holliday Kate L KL Hannemann Anke A Go Min Jin MJ Garcia Melissa M Polasek Ozren O Laaksonen Marika M Zhu Kun K Enneman Anke W AW McEvoy Mark M Peel Roseanne R Sham Pak Chung PC Jaworski Maciej M Johansson Åsa Å Hicks Andrew A AA Pludowski Pawel P Scott Rodney R Dhonukshe-Rutten Rosalie A M RA van der Velde Nathalie N Kähönen Mika M Viikari Jorma S JS Sievänen Harri H Raitakari Olli T OT González-Macías Jesús J Hernández Jose L JL Mellström Dan D Ljunggren Osten O Cho Yoon Shin YS Völker Uwe U Nauck Matthias M Homuth Georg G Völzke Henry H Haring Robin R Brown Matthew A MA McCloskey Eugene E Nicholson Geoffrey C GC Eastell Richard R Eisman John A JA Jones Graeme G Reid Ian R IR Dennison Elaine M EM Wark John J Boonen Steven S Vanderschueren Dirk D Wu Frederick C W FC Aspelund Thor T Richards J Brent JB Bauer Doug D Hofman Albert A Khaw Kay-Tee KT Dedoussis George G Obermayer-Pietsch Barbara B Gyllensten Ulf U Pramstaller Peter P PP Lorenc Roman S RS Cooper Cyrus C Kung Annie Wai Chee AW Lips Paul P Alen Markku M Attia John J Brandi Maria Luisa ML de Groot Lisette C P G M LC Lehtimäki Terho T Riancho José A JA Campbell Harry H Liu Yongmei Y Harris Tamara B TB Akesson Kristina K Karlsson Magnus M Lee Jong-Young JY Wallaschofski Henri H Duncan Emma L EL O'Neill Terence W TW Gudnason Vilmundur V Spector Timothy D TD Rousseau François F Orwoll Eric E Cummings Steven R SR Wareham Nick J NJ Rivadeneira Fernando F Uitterlinden Andre G AG Prince Richard L RL Kiel Douglas P DP Reeve Jonathan J Kaptoge Stephen K SK
Human molecular genetics 20140114 11
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independ ...[more]
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