Ontology highlight
ABSTRACT:
SUBMITTER: De Obaldia ME
PROVIDER: S-EPMC4038953 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
De Obaldia Maria Elena ME Bell J Jeremiah JJ Wang Xinxin X Harly Christelle C Yashiro-Ohtani Yumi Y DeLong Jonathan H JH Zlotoff Daniel A DA Sultana Dil Afroz DA Pear Warren S WS Bhandoola Avinash A
Nature immunology 20131103 12
Notch signaling induces gene expression of the T cell lineage and discourages alternative fate outcomes. Hematopoietic deficiency in the Notch target Hes1 results in severe T cell lineage defects; however, the underlying mechanism is unknown. We found here that Hes1 constrained myeloid gene-expression programs in T cell progenitor cells, as deletion of the myeloid regulator C/EBP-α restored the development of T cells from Hes1-deficient progenitor cells. Repression of Cebpa by Hes1 required its ...[more]