Ontology highlight
ABSTRACT:
SUBMITTER: Shang Y
PROVIDER: S-EPMC4955730 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shang Yingli Y Coppo Maddalena M He Teng T Ning Fei F Yu Li L Kang Lan L Zhang Bin B Ju Chanyang C Qiao Yu Y Zhao Baohong B Gessler Manfred M Rogatsky Inez I Hu Xiaoyu X
Nature immunology 20160620 8
Most of the known regulatory mechanisms that curb inflammatory gene expression target pre-transcription-initiation steps, and evidence for post-initiation regulation of inflammatory gene expression remains scarce. We found that the transcriptional repressor Hes1 suppressed production of CXCL1, a chemokine that is crucial for recruiting neutrophils. Hes1 negatively regulated neutrophil recruitment in vivo in a manner that was dependent on macrophage-produced CXCL1, and it attenuated the severity ...[more]