Ontology highlight
ABSTRACT:
SUBMITTER: Asmar F
PROVIDER: S-EPMC4039115 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Asmar Fazila F Hother Christoffer C Kulosman Gorjan G Treppendahl Marianne Bach MB Nielsen Helene Myrtue HM Ralfkiaer Ulrik U Pedersen Anja A Møller Michael Boe MB Ralfkiaer Elisabeth E de Nully Brown Peter P Grønbæk Kirsten K
Oncotarget 20140401 7
MiR34A, B and C have been implicated in lymphomagenesis, but information on their role in normal CD19+ B-cells (PBL-B) and de novo diffuse large B-cell lymphoma (DLBCL) is limited. We show that in normal and activated B-cells miR34A-5p plays a dominant role compared to other miR34 family members. Only miR34A-5p is expressed in PBL-B, and significantly induced in activated B-cells and reactive lymph nodes. In PBL-B, the MIR34A and MIR34B/C promoters are unmethylated, but the latter shows enrichme ...[more]