Dataset Information

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

ABSTRACT: Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients do, and others do not, report pain. To better understand central nervous system contributions to HIV DNP, we performed a cross-sectional analysis of structural magnetic resonance imaging volumes in 241 HIV-infected participants from an observational multi-site cohort study at five US sites (CNS HIV Anti-Retroviral Treatment Effects Research Study, CHARTER). The association between DNP and the structural imaging outcomes was investigated using both linear and nonlinear (Gaussian Kernel support vector) multivariable regression, controlling for key demographic and clinical variables. Severity of DNP symptoms was correlated with smaller total cerebral cortical gray matter volume (r?=?-0.24; p?=?0.004). Understanding the mechanisms for this association between smaller total cortical volumes and DNP may provide insight into HIV DNP chronicity and treatment-resistance.

SUBMITTER: Keltner JR

PROVIDER: S-EPMC4040150 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

Keltner John R JR Fennema-Notestine Christine C Vaida Florin F Wang Dongzhe D Franklin Donald R DR Dworkin Robert H RH Sanders Chelsea C McCutchan J Allen JA Archibald Sarah L SL Miller David J DJ Kesidis George G Cushman Clint C Kim Sung Min SM Abramson Ian I Taylor Michael J MJ Theilmann Rebecca J RJ Julaton Michelle D MD Notestine Randy J RJ Corkran Stephanie S Cherner Mariana M Duarte Nichole A NA Alexander Terry T Robinson-Papp Jessica J Gelman Benjamin B BB Simpson David M DM Collier Ann C AC Marra Christina M CM Morgello Susan S Brown Greg G Grant Igor I Atkinson J Hampton JH Jernigan Terry L TL Ellis Ronald J RJ

Journal of neurovirology 20140219 3

Despite modern antiretroviral therapy, HIV-associated sensory neuropathy affects over 50 % of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients d ...[more]

PMID: 24549970

Similar Datasets

Project description:This study aims to investigate the disrupted topological organization of gray matter (GM) structural networks in cerebral small vessel disease (CSVD) patients with cerebral microbleeds (CMBs). Subject-wise structural networks were constructed from GM volumetric features of 49 CSVD patients with CMBs (CSVD-c), 121 CSVD patients without CMBs (CSVD-n), and 74 healthy controls. The study used graph theory to analyze the global and regional properties of the network and their correlation with cognitive performance. We found that both the control and CSVD groups exhibited efficient small-world organization in GM networks. However, compared to controls, CSVD-c and CSVD-n patients exhibited increased global and local efficiency (Eglob/Eloc) and decreased shortest path lengths (Lp), indicating increased global integration and local specialization in structural networks. Although there was no significant global topology change, partially reorganized hub distributions were found between CSVD-c and CSVD-n patients. Importantly, regional topology in nonhub regions was significantly altered between CSVD-c and CSVD-n patients, including the bilateral anterior cingulate gyrus, left superior parietal gyrus, dorsolateral superior frontal gyrus, and right MTG, which are involved in the default mode network (DMN) and sensorimotor functional modules. Intriguingly, the global metrics (Eglob, Eloc, and Lp) were significantly correlated with MoCA, AVLT, and SCWT scores in the control group but not in the CSVD-c and CSVD-n groups. In contrast, the global metrics were significantly correlated with the SDMT score in the CSVD-s and CSVD-n groups but not in the control group. Patients with CSVD show a disrupted balance between local specialization and global integration in their GM structural networks. The altered regional topology between CSVD-c and CSVD-n patients may be due to different etiological contributions, which may offer a novel understanding of the neurobiological processes involved in CSVD with CMBs.

Dataset Information

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

Publications

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets