Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor.
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ABSTRACT:
SUBMITTER: Velagapudi SP
PROVIDER: S-EPMC4040211 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor.
Velagapudi Sai Pradeep SP Disney Matthew D MD
Chemical communications (Cambridge, England) 20140301 23
The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the "bottom-up" design of a small molecule inhibitor of oncogenic microRNA-10b. ...[more]
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