Ontology highlight
ABSTRACT:
SUBMITTER: Mejia E
PROVIDER: S-EPMC4040948 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
DNA repair 20140322
Protozoans of the genus Leishmania, the pathogenic agent causing leishmaniasis, encode the family X DNA polymerase Li Pol β. Here, we report the first crystal structures of Li Pol β. Our pre- and post-catalytic structures show that the polymerase adopts the common family X DNA polymerase fold. However, in contrast to other family X DNA polymerases, the dNTP-induced conformational changes in Li Pol β are much more subtle. Moreover, pre- and post-catalytic structures reveal that Li Pol β interacts ...[more]