Ontology highlight
ABSTRACT:
SUBMITTER: Schorn M
PROVIDER: S-EPMC4041076 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Schorn Michelle M Zettler Judith J Noel Joseph P JP Dorrestein Pieter C PC Moore Bradley S BS Kaysser Leonard L
ACS chemical biology 20131108 1
The epoxyketone proteasome inhibitors are an established class of therapeutic agents for the treatment of cancer. Their unique α',β'-epoxyketone pharmacophore allows binding to the catalytic β-subunits of the proteasome with extraordinary specificity. Here, we report the characterization of the first gene clusters for the biosynthesis of natural peptidyl-epoxyketones. The clusters for epoxomicin, the lead compound for the anticancer drug Kyprolis, and for eponemycin were identified in the actino ...[more]