Ontology highlight
ABSTRACT:
SUBMITTER: Lee MJ
PROVIDER: S-EPMC7675178 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Lee Min Jae MJ Bhattarai Deepak D Yoo Jisu J Miller Zach Z Park Ji Eun JE Lee Sukyeong S Lee Wooin W Driscoll James J JJ Kim Kyung Bo KB
Journal of medicinal chemistry 20190419 9
Over the past 15 years, proteasome inhibitors (PIs), namely bortezomib, carfilzomib (Cfz) and ixazomib, have significantly improved the overall survival and quality-of-life for multiple myeloma (MM) patients. However, a significant portion of MM patients do not respond to PI therapies. Drug resistance is present either de novo or acquired after prolonged therapy through mechanisms that remain poorly defined. The lack of a clear understanding of clinical PI resistance has hampered the development ...[more]