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APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent emphysema and examined gene expression in an independent sample. We then tested the association of a related lipid biomarker with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio and per cent emphysema. We identified one new polymorphism for FEV1/FVC (rs805301) in European-Americans (p=1.3×10(-6)) and a second (rs707974) in the combined European-American and African-American analysis (p=1.38×10(-7)). Both single-nucleotide polymorphisms (SNPs) flank the gene for apolipoprotein M (APOM), a component of high-density lipoprotein (HDL) cholesterol. Both were replicated in an independent cohort. SNPs in a second gene related to apolipoprotein M and HDL, PCSK9, were associated with FEV1/FVC ratio among African-Americans. rs707974 was associated with per cent emphysema among European-Americans and African-Americans and APOM expression was related to FEV1/FVC ratio and per cent emphysema. Higher HDL levels were associated with lower FEV1/FVC ratio and greater per cent emphysema. These findings suggest a novel role for the apolipoprotein M/HDL pathway in the pathogenesis of COPD and emphysema.

SUBMITTER: Burkart KM

PROVIDER: S-EPMC4041087 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.

Burkart Kristin M KM Manichaikul Ani A Wilk Jemma B JB Ahmed Firas S FS Burke Gregory L GL Enright Paul P Hansel Nadia N NN Haynes Demondes D Heckbert Susan R SR Hoffman Eric A EA Kaufman Joel D JD Kurai Jun J Loehr Laura L London Stephanie J SJ Meng Yang Y O'Connor George T GT Oelsner Elizabeth E Petrini Marcy M Pottinger Tess D TD Powell Charles A CA Redline Susan S Rotter Jerome I JI Smith Lewis J LJ Soler Artigas María M Tobin Martin D MD Tsai Michael Y MY Watson Karol K White Wendy W Young Taylor R TR Rich Stephen S SS Barr R Graham RG

The European respiratory journal 20130730 4

Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD. We assessed the association of lung function with 2100 genes selected for cardiovascular diseases among 20 077 European-Americans and 6900 African-Americans. We performed replication of significant loci in the other racial group and an independent consortium of Europeans, tested the associations of significant loci with per cent e ...[more]

PMID: 23900982

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Dataset Information

APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.

Publications

APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema.

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