Ontology highlight
ABSTRACT:
SUBMITTER: Heller E
PROVIDER: S-EPMC4041280 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Heller Evan E Kumar K Vijay KV Grill Stephan W SW Fuchs Elaine E
Developmental cell 20140301 6
While gastrulation movements offer mechanistic paradigms for how collective cellular movements shape developing embryos, far less is known about coordinated cellular movements that occur later in development. Studying eyelid closure, we explore a case where an epithelium locally reshapes, expands, and moves over another epithelium. Live imaging, gene targeting, and cell-cycle inhibitors reveal that closure does not require overlying periderm, proliferation, or supracellular actin cable assembly. ...[more]