Ontology highlight
ABSTRACT:
SUBMITTER: Ellis SJ
PROVIDER: S-EPMC6638572 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ellis Stephanie J SJ Gomez Nicholas C NC Levorse John J Mertz Aaron F AF Ge Yejing Y Fuchs Elaine E
Nature 20190515 7757
Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imaging, lineage tracing, single-cell transcriptomics and genetics, we identify two cell competition mechanisms that sequentially shape and maintain the architecture of stratified tissue ...[more]