Ontology highlight
ABSTRACT:
SUBMITTER: Shen T
PROVIDER: S-EPMC4042171 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Shen Tao T Sun Chuang C Zhang Zhengmao Z Xu Ningyi N Duan Xueyan X Feng Xin-Hua XH Lin Xia X
Cell research 20140415 6
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily of structurally related signaling proteins that regulate a wide array of cellular functions. The key step in BMP signal transduction is the BMP receptor-mediated phosphorylation of transcription factors Smad1, 5, and 8 (collectively Smad1/5/8), which leads to the subsequent activation of BMP-induced gene transcription in the nucleus. In this study, we describe the identification and characterization of PPM1H as a novel cytoplasm- ...[more]