Ontology highlight
ABSTRACT:
SUBMITTER: Gulaka PK
PROVIDER: S-EPMC4043141 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20131127 2
Tumor hypoxia is known to affect sensitivity to radiotherapy and promote development of metastases; therefore, the ability to image tumor hypoxia in vivo could provide useful prognostic information and help tailor therapy. We previously demonstrated in vitro evidence for selective accumulation of a gadolinium tetraazacyclododecanetetraacetic acid monoamide conjugate of 2-nitroimidazole (GdDO3NI), a magnetic resonance imaging T1-shortening agent, in hypoxic cells grown in tissue culture. We now r ...[more]