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A second generation MRI contrast agent for imaging zinc ions in vivo.


ABSTRACT: A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.

SUBMITTER: De Leon-Rodriguez LM 

PROVIDER: S-EPMC3763856 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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A second generation MRI contrast agent for imaging zinc ions <i>in vivo.</i>

De León-Rodríguez Luis M LM   Lubag Angelo J M AJ   López Jorge A JA   Andreu-de-Riquer Gabriel G   Alvarado-Monzón José C JC   Sherry A Dean AD  

MedChemComm 20120401 4


A Zn<sup>2+</sup> specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn<sup>2+</sup> binding agent, the new agent binds to human albumin both in the presence and absence of Zn<sup>2+</sup>. ...[more]

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