Ontology highlight
ABSTRACT:
SUBMITTER: Aix E
PROVIDER: S-EPMC4896054 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Aix Esther E Gutiérrez-Gutiérrez Óscar Ó Sánchez-Ferrer Carlota C Aguado Tania T Flores Ignacio I
The Journal of cell biology 20160530 5
The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest. We show that telomerase activity and cardiomyocyte telomere length decrease sharply in wild-type mouse hearts after birth, resulting in cardiomyocytes with dysfunctional telomeres and anaphase bridges and positive for the cell-cycle arrest protein p21. We further s ...[more]