Ontology highlight
ABSTRACT:
SUBMITTER: Vear SI
PROVIDER: S-EPMC4043918 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
British journal of haematology 20140306 6
The influence of genetic variation on warfarin dose requirement is limited for paediatric patients. We performed a retrospective, cross-sectional study to examine the effect of variant CYP2C9 and VKORC1 genotypes on warfarin dose in 100 children. Those with VKORC1 genotype AA required 48% of the dose of homozygous wild-type (GG, P < 0·0001). Patients with any variant CYP2C9 allele required 71% of the dose for wild-type (P = 0·001). The effect of variant VKORC1 alleles tended to vary with age, su ...[more]