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ABSTRACT: Aim
To evaluate applicability of CYP2C9*2, *3 and VKORC1-1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.Patients & methods
Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.Results
Frequency of CYP2C9*2, *3 and VKORC1-1639G > A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R2 = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R2 = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7).Conclusion
The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.
SUBMITTER: Ayesh BM
PROVIDER: S-EPMC5859345 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ayesh Basim Mohammad BM Abu Shaaban Ahmed Shaker AS Abed Abdalla Asaf AA
Future science OA 20180110 3
<h4>Aim</h4>To evaluate applicability of <i>CYP2C9*2</i>, <i>*3</i> and <i>VKORC1-1639G > A</i> based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.<h4>Patients & methods</h4>Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.<h4>Results</h4>Frequency of <i>CYP2C9*2</i>, <i>*3</i> and <i>VKORC1-1639G > A</i> alleles ...[more]