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Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine.

ABSTRACT: Aim:To evaluate applicability of CYP2C9*2, *3 and VKORC1-1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods:Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results:Frequency of CYP2C9*2, *3 and VKORC1-1639G > A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R2 = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R2 = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7). Conclusion:The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.

SUBMITTER: Ayesh BM 

PROVIDER: S-EPMC5859345 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Evaluation of <i>CYP2C9</i>- and <i>VKORC1</i>-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine.

Ayesh Basim Mohammad BM   Abu Shaaban Ahmed Shaker AS   Abed Abdalla Asaf AA  

Future science OA 20180110 3

<h4>Aim</h4>To evaluate applicability of <i>CYP2C9*2</i>, <i>*3</i> and <i>VKORC1-1639G > A</i> based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.<h4>Patients & methods</h4>Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.<h4>Results</h4>Frequency of <i>CYP2C9*2</i>, <i>*3</i> and <i>VKORC1-1639G > A</i> alleles  ...[more]

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