Genetic determinants and cellular constraints in noisy gene expression.
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ABSTRACT:
SUBMITTER: Sanchez A
PROVIDER: S-EPMC4045091 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Genetic determinants and cellular constraints in noisy gene expression.
Sanchez Alvaro A Golding Ido I
Science (New York, N.Y.) 20131201 6163
In individual cells, transcription is a random process obeying single-molecule kinetics. Often, it occurs in a bursty, intermittent manner. The frequency and size of these bursts affect the magnitude of temporal fluctuations in messenger RNA and protein content within a cell, creating variation or "noise" in gene expression. It is still unclear to what degree transcriptional kinetics are specific to each gene and determined by its promoter sequence. Alternative scenarios have been proposed, in w ...[more]
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