Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.
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ABSTRACT:
SUBMITTER: Koran ME
PROVIDER: S-EPMC4045094 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.
Koran Mary Ellen I ME Hohman Timothy J TJ Thornton-Wells Tricia A TA
Human genetics 20130912 1
Late-onset Alzheimer's disease (LOAD) is known to have a complex, oligogenic etiology, with considerable genetic heterogeneity. We investigated the influence of genetic interactions between genes in the Alzheimer's disease (AD) pathway on amyloid-beta (Aβ) deposition as measured by PiB or AV-45 ligand positron emission tomography (PET) to aid in understanding LOAD's genetic etiology. Subsets of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts were used for discovery and for two ind ...[more]
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