Ontology highlight
ABSTRACT:
SUBMITTER: Mu X
PROVIDER: S-EPMC4046169 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Mu Xiaodong X Usas Arvydas A Tang Ying Y Lu Aiping A Wang Bing B Weiss Kurt K Huard Johnny J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130523 9
Heterotopic ossification (HO) and fatty infiltration (FI) often occur in diseased skeletal muscle and have been previously described in various animal models of Duchenne muscular dystrophy (DMD); however, the pathological mechanisms remain largely unknown. Dystrophin-deficient mdx mice and dystrophin/utrophin double-knockout (dKO) mice are mouse models of DMD; however, mdx mice display a strong muscle regeneration capacity, while dKO mice exhibit a much more severe phenotype, which is similar to ...[more]