Ontology highlight
ABSTRACT:
SUBMITTER: Bolcun-Filas E
PROVIDER: S-EPMC4048839 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Bolcun-Filas Ewelina E Rinaldi Vera D VD White Michelle E ME Schimenti John C JC
Science (New York, N.Y.) 20140101 6170
Genetic errors in meiosis can lead to birth defects and spontaneous abortions. Checkpoint mechanisms of hitherto unknown nature eliminate oocytes with unrepaired DNA damage, causing recombination-defective mutant mice to be sterile. Here, we report that checkpoint kinase 2 (Chk2 or Chek2), is essential for culling mouse oocytes bearing unrepaired meiotic or induced DNA double-strand breaks (DSBs). Female infertility caused by a meiotic recombination mutation or irradiation was reversed by mutati ...[more]