Gramicidin D enhances the antibacterial activity of fluoride.
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ABSTRACT:
SUBMITTER: Nelson JW
PROVIDER: S-EPMC4048840 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Gramicidin D enhances the antibacterial activity of fluoride.
Nelson James W JW Zhou Zhiyuan Z Breaker Ronald R RR
Bioorganic & medicinal chemistry letters 20140328 13
Fluoride is a toxic anion found in many natural environments. One of the major bacterial defenses against fluoride is the cell envelope, which limits passage of the membrane-impermeant fluoride anion. Accordingly, compounds that enhance the permeability of bacterial membranes to fluoride should also enhance fluoride toxicity. In this study, we demonstrate that the pore-forming antibiotic gramicidin D increases fluoride uptake in Bacillus subtilis and that the antibacterial activity of this compo ...[more]
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