Fluoride enhances the activity of fungicides that destabilize cell membranes.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC4498161 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Fluoride enhances the activity of fungicides that destabilize cell membranes.
Li Sanshu S Breaker Ronald R RR
Bioorganic & medicinal chemistry letters 20120308 9
Fluoride has long been known to inhibit bacterial and fungal cell growth most likely by blocking the functions of key metabolic enzymes. In this study, we demonstrate that antifungal compounds that disrupt cell membrane integrity exhibit improved ability to inhibit cell growth when used with millimolar concentrations of fluoride. Specifically, antifungal compounds of the polyene class and an antifungal peptide exhibit synergy with fluoride to inhibit the growth of various fungal species, includi ...[more]
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