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Ligand-enabled γ-C-H olefination and carbonylation: construction of β-quaternary carbon centers.

ABSTRACT: Monoselective γ-C-H olefination and carbonylation of aliphatic acids has been accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide directing group. The reaction provides a new route for constructing richly functionalized all-carbon quaternary carbon centers at the β-position of aliphatic acids.

SUBMITTER: Li S

PROVIDER: S-EPMC4049142 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Stereocontrolled alkylative construction of quaternary carbon centers.

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Ligand-Enabled γ-C(sp(3))-H Olefination of Amines: En Route to Pyrrolidines.

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Lewis Acid Catalyzed Transfer Hydromethallylation for the Construction of Quaternary Carbon Centers.

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Highly Diastereoselective Construction of Carbon- Heteroatom Quaternary Stereogenic Centers in the Synthesis of Analogs of Bioactive Compounds: From Monofluorinated Epoxyalkylphosphonates to α-Fluoro-, β-, or γ-Amino Alcohol Derivatives of Alkylphosphonates.

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| S-EPMC7519689 | biostudies-literature

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