Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh KK
PROVIDER: S-EPMC7496353 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200518 31
We report the ligand-enabled C-H activation/olefination of free carboxylic acids in the γ-position. Through an intramolecular Michael addition, δ-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the γ-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the ...[more]