Unknown

Dataset Information

0

Intestinal microbial diversity during early-life colonization shapes long-term IgE levels.


ABSTRACT: Microbial exposure following birth profoundly impacts mammalian immune system development. Microbiota alterations are associated with increased incidence of allergic and autoimmune disorders with elevated serum IgE as a hallmark. The previously reported abnormally high serum IgE levels in germ-free mice suggests that immunoregulatory signals from microbiota are required to control basal IgE levels. We report that germ-free mice and those with low-diversity microbiota develop elevated serum IgE levels in early life. B cells in neonatal germ-free mice undergo isotype switching to IgE at mucosal sites in a CD4 T-cell- and IL-4-dependent manner. A critical level of microbial diversity following birth is required in order to inhibit IgE induction. Elevated IgE levels in germ-free mice lead to increased mast-cell-surface-bound IgE and exaggerated oral-induced systemic anaphylaxis. Thus, appropriate intestinal microbial stimuli during early life are critical for inducing an immunoregulatory network that protects from induction of IgE at mucosal sites.

SUBMITTER: Cahenzli J 

PROVIDER: S-EPMC4049278 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4648652 | biostudies-literature
2022-12-23 | GSE221568 | GEO
| S-EPMC6611565 | biostudies-literature
| S-EPMC4446945 | biostudies-literature
| S-EPMC4409162 | biostudies-literature
| S-EPMC6092392 | biostudies-literature
| S-EPMC3245219 | biostudies-literature
| S-EPMC8666517 | biostudies-literature
| S-EPMC7838415 | biostudies-literature
2014-05-02 | E-GEOD-54077 | biostudies-arrayexpress