Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.
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ABSTRACT:
SUBMITTER: Johansson ME
PROVIDER: S-EPMC4648652 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Publications
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.
Johansson Malin E V ME Jakobsson Hedvig E HE Holmén-Larsson Jessica J Schütte André A Ermund Anna A Rodríguez-Piñeiro Ana M AM Arike Liisa L Wising Catharina C Svensson Frida F Bäckhed Fredrik F Hansson Gunnar C GC
Cell host & microbe 20151029 5
The intestinal mucus layer provides a barrier limiting bacterial contact with the underlying epithelium. Mucus structure is shaped by intestinal location and the microbiota. To understand how commensals modulate gut mucus, we examined mucus properties under germ-free (GF) conditions and during microbial colonization. Although the colon mucus organization of GF mice was similar to that of conventionally raised (Convr) mice, the GF inner mucus layer was penetrable to bacteria-sized beads. During c ...[more]
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