Chemical exchange in biomacromolecules: past, present, and future.
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ABSTRACT:
SUBMITTER: Palmer AG
PROVIDER: S-EPMC4049312 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Chemical exchange in biomacromolecules: past, present, and future.
Journal of magnetic resonance (San Diego, Calif. : 1997) 20140401
The perspective reviews quantitative investigations of chemical exchange phenomena in proteins and other biological macromolecules using NMR spectroscopy, particularly relaxation dispersion methods. The emphasis is on techniques and applications that quantify the populations, interconversion kinetics, and structural features of sparsely populated conformational states in equilibrium with a highly populated ground state. Applications to folding, molecular recognition, catalysis, and allostery by ...[more]
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