Ontology highlight
ABSTRACT:
SUBMITTER: Querec TD
PROVIDER: S-EPMC4049462 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Querec Troy D TD Akondy Rama S RS Lee Eva K EK Cao Weiping W Nakaya Helder I HI Teuwen Dirk D Pirani Ali A Gernert Kim K Deng Jiusheng J Marzolf Bruz B Kennedy Kathleen K Wu Haiyan H Bennouna Soumaya S Oluoch Herold H Miller Joseph J Vencio Ricardo Z RZ Mulligan Mark M Aderem Alan A Ahmed Rafi R Pulendran Bali B
Nature immunology 20081123 1
A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with yellow fever vaccine YF-17D. Vaccination induced genes that regulate virus innate sensing and type I interferon production. Computational analyses identified a gene signature, including complement protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orche ...[more]