Immunogenicity and safety of primary fractional-dose yellow fever vaccine in autoimmune rheumatic diseases.

ABSTRACT:

Background

Brazil faced a yellow fever(YF) outbreak in 2016-2018 and vaccination was considered for autoimmune rheumatic disease patients(ARD) with low immunosuppression due to YF high mortality.

Objective

This study aimed to evaluate, prospectively for the first time, the short-term immunogenicity of the fractional YF vaccine(YFV) immunization in ARD patients with low immunossupression.

Methods and results

A total of 318 participants(159 ARD and 159 age- and sex-matched healthy controls) were vaccinated with the fractional-dose(one fifth) of 17DD-YFV. All subjects were evaluated at entry(D0), D5, D10, and D30 post-vaccination for clinical/laboratory and disease activity parameters for ARD patients. Post-vaccination seroconversion rate(83.7%vs.96.6%, p = 0.0006) and g

SUBMITTER: Tonacio AC 

PROVIDER: S-EPMC8659329 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature