Ontology highlight
ABSTRACT:
SUBMITTER: Majeed SR
PROVIDER: S-EPMC4050264 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Majeed Sophia R SR Vasudevan Lavanya L Chen Chih-Ying CY Luo Yi Y Torres Jorge A JA Evans Timothy M TM Sharkey Andrew A Foraker Amy B AB Wong Nicole M L NM Esk Christopher C Freeman Theresa A TA Moffett Ashley A Keen James H JH Brodsky Frances M FM
Nature communications 20140523
The clathrin light chain (CLC) subunits participate in several membrane traffic pathways involving both clathrin and actin, through binding the actin-organizing huntingtin-interacting proteins (Hip). However, CLCs are dispensable for clathrin-mediated endocytosis of many cargoes. Here we observe that CLC depletion affects cell migration through Hip binding and reduces surface expression of β1-integrin by interference with recycling following normal endocytosis of inactive β1-integrin. CLC deplet ...[more]