Ontology highlight
ABSTRACT:
SUBMITTER: Schreij AM
PROVIDER: S-EPMC4304731 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Schreij Andrea M A AM Chaineau Mathilde M Ruan Wenjing W Lin Susan S Barker Philip A PA Fon Edward A EA McPherson Peter S PS
EMBO reports 20141126 1
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of dominant-inherited Parkinson's disease (PD), and yet we do not fully understand the physiological function(s) of LRRK2. Various components of the clathrin machinery have been recently found mutated in familial forms of PD. Here, we provide molecular insight into the association of LRRK2 with the clathrin machinery. We report that through its GTPase domain, LRRK2 binds directly to clathrin-light chains (CLCs). Using ge ...[more]