Ontology highlight
ABSTRACT:
SUBMITTER: Qian X
PROVIDER: S-EPMC4051865 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Qian X X Anzovino A A Kim S S Suyama K K Yao J J Hulit J J Agiostratidou G G Chandiramani N N McDaid H M HM Nagi C C Cohen H W HW Phillips G R GR Norton L L Hazan R B RB
Oncogene 20130826 26
N-cadherin and HER2/neu were found to be co-expressed in invasive breast carcinomas. To test the contribution of N-cadherin and HER2 in mammary tumor metastasis, we targeted N-cadherin expression in the mammary epithelium of the MMTV-Neu mouse. In the context of ErbB2/Neu, N-cadherin stimulated carcinoma cell invasion, proliferation and metastasis. N-cadherin caused fibroblast growth factor receptor (FGFR) upmodulation, resulting in epithelial-to-mesenchymal transition (EMT) and stem/progenitor ...[more]