Ontology highlight
ABSTRACT:
SUBMITTER: Clause A
PROVIDER: S-EPMC4052368 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Clause Amanda A Kim Gunsoo G Sonntag Mandy M Weisz Catherine J C CJ Vetter Douglas E DE Rűbsamen Rudolf R Kandler Karl K
Neuron 20140501 4
Patterned spontaneous activity is a hallmark of developing sensory systems. In the auditory system, rhythmic bursts of spontaneous activity are generated in cochlear hair cells and propagated along central auditory pathways. The role of these activity patterns in the development of central auditory circuits has remained speculative. Here we demonstrate that blocking efferent cholinergic neurotransmission to developing hair cells in mice that lack the α9 subunit of nicotinic acetylcholine recepto ...[more]