Ontology highlight
ABSTRACT:
SUBMITTER: Cheema AK
PROVIDER: S-EPMC4053308 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Cheema Amrita K AK Pathak Rupak R Zandkarimi Fereshteh F Kaur Prabhjit P Alkhalil Lynn L Singh Rajbir R Zhong Xiaogang X Ghosh Sanchita S Aykin-Burns Nukhet N Hauer-Jensen Martin M
Journal of proteome research 20140522 6
Although radiation-induced tissue-specific injury is well documented, the underlying molecular changes resulting in organ dysfunction and the consequences thereof on overall metabolism and physiology have not been elucidated. We previously reported the generation and characterization of a transgenic mouse strain that ubiquitously overexpresses Gfrp (GTPH-1 feedback regulatory protein) and exhibits higher oxidative stress, which is a possible result of decreased tetrahydrobiopterin (BH4) bioavail ...[more]