Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria.
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ABSTRACT:
SUBMITTER: Ranji P
PROVIDER: S-EPMC4053411 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria.
Ranji Parmida P Rauthan Manish M Pitot Christophe C Pilon Marc M
PloS one 20140611 2
HMG-CoA reductase is the rate-limiting enzyme in the mevalonate pathway and the target of cholesterol-lowering statins. We characterized the C. elegans hmgr-1(tm4368) mutant, which lacks HMG-CoA reductase, and show that its phenotypes recapitulate that of statin treatment, though in a more severe form. Specifically, the hmgr-1(tm4368) mutant has defects in growth, reproduction and protein prenylation, is rescued by exogenous mevalonate, exhibits constitutive activation of the UPRer and requires ...[more]
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