Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4053837 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wang Yuchen Y Karu Kersti K Meljon Anna A Turton John J Yau Joyce L JL Seckl Jonathan R JR Wang Yuqin Y Griffiths William J WJ
Biochemical and biophysical research communications 20140514 2
24S,25-Epoxycholesterol is formed in a shunt of the mevalonate pathway that produces cholesterol. It is one of the most potent known activators of the liver X receptors and can inhibit sterol regulatory element-binding protein processing. Until recently analysis of 24S,25-epoxycholesterol at high sensitivity has been precluded by its thermal lability and lack of a strong chromophore. Here we report on the analysis of 24S,25-epoxycholesterol in rodent brain where its level was determined to be of ...[more]