Ontology highlight
ABSTRACT:
SUBMITTER: Chiappelli J
PROVIDER: S-EPMC7680117 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chiappelli Joshua J Quinton Maria S MS Volfson Dmitri D Cwik Michael M Marshall Wyatt W Bruce Heather H Goldwaser Eric E Kvarta Mark M Summerfelt Ann A Kochunov Peter P O'Donnell Patricio P Hong Liyi Elliot LE
NPJ schizophrenia 20201120 1
Plasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain structures, 24S-hydroxycholesterol is a promising biomarker for psychiatric and neurologic disorders that impact brain structure. We hypothesized that, as schizophrenia patients have widely reported gray and white matter deficits, they would have abnormal levels of plasma 24S-hydroxycholestero ...[more]