Ontology highlight
ABSTRACT:
SUBMITTER: Fukunaga T
PROVIDER: S-EPMC4053987 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Genome biology 20140121 1
RNA-binding proteins (RBPs) bind to their target RNA molecules by recognizing specific RNA sequences and structural contexts. The development of CLIP-seq and related protocols has made it possible to exhaustively identify RNA fragments that bind to RBPs. However, no efficient bioinformatics method exists to reveal the structural specificities of RBP-RNA interactions using these data. We present CapR, an efficient algorithm that calculates the probability that each RNA base position is located wi ...[more]