Ontology highlight
ABSTRACT:
SUBMITTER: Cereda M
PROVIDER: S-EPMC4054596 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cereda Matteo M Pozzoli Uberto U Rot Gregor G Juvan Peter P Schweitzer Anthony A Clark Tyson T Ule Jernej J
Genome biology 20140131 1
RNA-binding proteins (RBPs) regulate splicing according to position-dependent principles, which can be exploited for analysis of regulatory motifs. Here we present RNAmotifs, a method that evaluates the sequence around differentially regulated alternative exons to identify clusters of short and degenerate sequences, referred to as multivalent RNA motifs. We show that diverse RBPs share basic positional principles, but differ in their propensity to enhance or repress exon inclusion. We assess exo ...[more]