Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC4055034 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Deng Lin L Baldissard Suzanne S Kettenbach Arminja N AN Gerber Scott A SA Moseley James B JB
Current biology : CB 20140206 4
Cell size control requires mechanisms that integrate cell growth and division. Key to this integration in fission yeast is the SAD family kinase Cdr2, which organizes a set of cortical nodes in the cell middle to promote mitotic entry through Wee1 and Cdk1. Cdr2 is inhibited by a spatial gradient of the DYRK kinase Pom1 emanating from cell tips in a cell-size-dependent manner, but how the Pom1 gradient inhibits Cdr2 activity during cell growth is unknown. Here, we show that Pom1 acts to prevent ...[more]